Unsere Teams

Wissenschaftliche Leiter des DBA Forschungsprojekts

PROF. JOSEF PENNINGER, GRÜNDUNGSDIREKTOR IMBA

“Wir wollen ungeklärte Fragen der Biologie enträtseln. Diese Erkenntnisse sind die Basis für Fortschritte in der modernen Medizin.”

PROFESSOR DR. JAVIER MARTINEZ, CENTER FOR MEDICAL BIOCHEMISTRY (DIVISION OF MOLECULAR GENETICS) MEDICAL UNIVERSITY VIENNA

„In unserem Forschungsteam haben wir eine bahnbrechende Theorie entwickelt, die wir jetzt mithilfe modernster Stammzelletechnologie erforschen. Wenn wir Recht haben, werden unsere Ergebnisse bisher ungesehene Facetten der DBA-Biologie aufdecken und die Entwicklung neuer Therapeutika ermöglichen, die die Behandlung von DBA revolutionieren werden“.

Penninger Lab/IMBA

Astrid Hagelkruys, Senior Research Associate
Bianca Gapp, Postdoc

Team Members:
Geert de Vries
(Master student)
Yannik Thüringer (Master student)
Irma Sakic (Internship student)

Short abstract explaining research
of Bianca Gapp

GENETIC SCREENING TO IDENTIFY SUPPRESSORS OF DIAMOND- BLACKFAN ANEMIA
Annual DBA update meeting Bianca Gapp – Penninger Lab 23rd of June 2020

FACTS/ABSTRACT
Humans are complex organisms that are comprised of billions of cells. Each human cell contains 2 meters of DNA that is packed up in the nucleus in a very sophisticated way. This 2 meter DNA stretch encodes over 20 thousand genes (= the blueprint for proteins) that give rise to over 300 thousand proteins (= the stuff that actually makes a human body work). To scan the human genome for mutations that could compensate for DBA causing mutations, we mutate 120 million cells so we hit each of the over 20.000 human genes several times.
We than isolate the DNA and sequence all this 120 million mutations at the same time on a so-called next generation sequencing machine. The generation and culturing of these 120 million cells takes several weeks, the sequencing of all the mutation in parallel is done in 24 hours.

Martinez Lab/Max Perutz Labs

Devon Germain, Postdoc

Team Members:
Daniela Zwolanek
Stefan Weitzer

Short abstract explaining research
of Devon Germain

Diamond-Blackfan anemia, towards a better understanding and new treatments
Martinez group, Max Perutz Lab, Vienna

FACTS/ABSTRACT
In preparation for future experiments, Bianca and I counted and stocked 670.100.000 cells. Differentiating induced pluripotent stem cells into early red blood cell progenitors take 23 days.For the generation of our genetically modified IPSC lines over 200 individual colonies were collected and analysed. When not in use, cells are stored below -150⁰C in liquid nitrogen.

Stem Cell Facility/IMBA

Sofia Aligianni, Co-Head SCCF
Jennifer Volz, Co-Head SCCF

Team Members:
Michelle Foong-Sobis, Research Assistant SCCF
Manuela Kinzer, Research Assistant SCCF
Nicole Leeb, Research Assistant SCCF
Miroslava Peterkova, Research Assistant SCCF
Elisabeth Stein, Research Assistant SCCF

Stem Cell Facility_Abschlussbericht
IMBA Stammzell-Facility, Dr. Jennifer Volz

%d bloggers like this: